Treatments

Studies have backed in the last years the positive effects of Cannabidiol in patients suffering with seizures and epilepsy.

Epilepsia y Convulciones

Marijuana: An Effective Antiepileptic Treatment in Partial Epilepsy? A Case Report and Review of the Literature (2007)

Abstract

Although more data are needed, animal studies and clinical experience suggest that marijuana or its active constituents may have a place in the treatment of partial epilepsy. Here we present the case of a 45-year-old man with cerebral palsy and epilepsy who showed marked improvement with the use of marijuana[…]

Author Information

Mortati K, Dworetzky B, Devinsky O.

Department of Neurology, New York University School of Medicine, New York, NY, USA

Evidence for cannabis and cannabinoids for epilepsy: a systematic review of controlled and observational evidence (2018)

Abstract

Review evidence for cannabinoids as adjunctive treatments for treatment-resistant epilepsy. Systematic search of Medline, Embase and PsycINFO was conducted in October 2017. Outcomes were: 50%+ seizure reduction, complete seizure freedom; improved quality of life (QoL). Tolerability/safety were assessed by study withdrawals, adverse events (AEs) and serious adverse events (SAEs). Analyses were conducted in Stata V.15.0. 36 studies were identified: 6 randomised controlled trials (RCTs), 30 observational studies[…]

Author Information

Emily Stockings, Dino Zagic, Gabrielle Campbell, Megan Weier, Wayne D Hall, Suzanne Nielsen, Geoffrey K Herkes, Michael Farrell, Louisa Degenhardt

National Drug and Alcohol Research Centre, UNSW Sydney, Sydney, New South Wales, Australia. Centre for Youth Substance Abuse Research, University of Queensland, Brisbane, Queensland, Australia. National Addiction Centre, Kings College London, London, England. Department of Neurology, Royal North Shore Hospital, Sydney, New South Wales, Australia

The Interplay between the Endocannabinoid System, Epilepsy and Cannabinoids. (2019)

Abstract

Epilepsy is a neurological disorder that affects approximately 50 million people worldwide. There is currently no definitive epilepsy cure. However, in recent years, medicinal cannabis has been successfully trialed as an effective treatment for managing epileptic symptoms, but whose mechanisms of action are largely unknown. Lately, there has been a focus on neuroinflammation as an important factor in the pathology of many epileptic disorders[…]

Author Information

Cheung KAK, Peiris H, Wallace G, Holland OJ, Mitchell MD.

Institute of Health and Biomedical Innovation (IHBI), Faculty of Health, Queensland University of Technology (QUT), Centre for Children’s Health Research (CCHR), 62 Graham Street, South Brisbane, QLD 4101, Australia. Children’s Health Queensland (CHQ) and University of Queensland (UQ), Centre for Children’s Health Research, 62 Graham Street, South Brisbane, QLD 4101, Australia. School of Medical Science, Griffith University, 1 Parklands Dr, Southport, QLD 4215, Australia.

Cannabinoids and Epilepsy. (2015)

Abstract

Cannabis has been used for centuries to treat seizures. Recent anecdotal reports, accumulating animal model data, and mechanistic insights have raised interest in cannabis-based antiepileptic therapies. In this study, we review current understanding of the endocannabinoid system, characterize the pro- and anticonvulsive effects of cannabinoids [e.g., Δ9-tetrahydrocannabinol and cannabidiol (CBD)], and highlight scientific evidence from pre-clinical and clinical trials of cannabinoids in epilepsy[…]

Author Information

Rosenberg EC, Tsien RW, Whalley BJ, Devinsky O.

Department of Neuroscience and Physiology, Neuroscience Institute, NYU Langone Medical Center, New York, NY, 10016, USA. School of Pharmacy, The University of Reading, Whiteknights, Reading, RG6 6AP, UK. Department of Neurology, Comprehensive Epilepsy Center, New York University School of Medicine, New York, NY, 10016, UK. od4@nyu.edu.

Therapeutic effects of cannabinoids in animal models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection. (2017)

Abstract

The isolation and identification of the discrete plant cannabinoids in marijuana revived interest in analyzing historical therapeutic claims made for cannabis in clinical case studies and anecdotes. In particular, sources as old as the 11th and 15th centuries claimed efficacy for crude marijuana extracts in the treatment of convulsive disorders, prompting a particularly active area of preclinical research into the therapeutic potential of plant cannabinoids in epilepsy[…]

Author Information

Rosenberg EC, Patra PH, Whalley BJ.

Department of Neuroscience and Physiology, Neuroscience Institute, NYU Langone Medical Center, New York, NY 10016, USA. Department of Pharmacy, School of Chemistry, Food & Nutritional Sciences and Pharmacy, University of Reading, Whiteknights, Reading, Berkshire RG6 6AP, UK. Department of Pharmacy, School of Chemistry, Food & Nutritional Sciences and Pharmacy, University of Reading, Whiteknights, Reading, Berkshire RG6 6AP, UK. Electronic address: b.j.whalley@reading.ac.uk.

Cannabinoids in treatment-resistant epilepsy: A review. (2017)

Abstract

Treatment-resistant epilepsy (TRE) affects 30% of epilepsy patients and is associated with severe morbidity and increased mortality. Cannabis-based therapies have been used to treat epilepsy for millennia, but only in the last few years have we begun to collect data from adequately powered placebo-controlled, randomized trials (RCTs) with cannabidiol (CBD), a cannabis derivative[…]

Author Information

O’Connell BK, Gloss D, Devinsky O.

NYU Epilepsy Center, New York, NY, United States. CAMC, Charleston, WV, United States. NYU Epilepsy Center, New York, NY, United States. Electronic address: Od4@nyu.edu.

Treatments
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